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Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 596-609 doi: 10.1007/s11684-021-0868-z

Abstract: Sialic acid binding Ig-like lectin 10 (Siglec10) is a member of innate immune checkpoints that inhibitsthe activation of immune cells through the interaction with its ligand CD24 on tumor cells.

Keywords： innate immune checkpoint     Siglec10     kidney renal clear cell carcinoma    

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Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 33-42 doi: 10.1007/s11684-019-0735-3

Abstract: Immunotherapy has recently led to a paradigm shift in cancer therapy, in which immune checkpoint inhibitorsnon-specific activation of effector T cells, ICIs are remarkably associated with a substantial risk of immune-related

Keywords： cancer     immunotherapy     immune checkpoint inhibitors     immune-related adverse events     review    

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Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases

Zhen Xiang, Yingyan Yu

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 24-31 doi: 10.1007/s11684-019-0679-7

Abstract: Immune checkpoint inhibitors are a promising strategy in the treatment of cancer, especially advancedHowever, not all patients are responsive to immune checkpoint inhibitors.of immune checkpoint proteins, and molecular subtypes of cancers.checkpoint inhibitors.overcoming resistance, and indications for immune checkpoint inhibitor therapy.

Keywords： immune checkpoint blockade     sensitivity     resistance     data mining    

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Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 229-235 doi: 10.1007/s11684-017-0581-0

Abstract: MSI-H status due to dMMR and characterized by increased neoantigen load, which elicits intense host immune

Keywords： molecular classification     precision medicine     pembrolizumab     PD-1/PD-L1     MSI-H    

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Innate immune responses in RNA viral infection

Qian Xu, Yuting Tang, Gang Huang

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 333-346 doi: 10.1007/s11684-020-0776-7

Abstract: Upon viral invasion, the innate immune system responds rapidly and plays a key role in activating theadaptive immune system.In the innate immune system, the interactions between pathogen-associated molecular patterns and hostMacrophages, dendritic cells, and natural killer cells are the principal innate immune components thatThis knowledge provides an enhanced understanding of the innate immune response to RNA viral infections

Keywords： innate immune     viral infection     intercellular signaling     metabolic changes     epigenetic changes    

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Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 307-321 doi: 10.1007/s11684-022-0927-0

Abstract: The discovery of immune checkpoint inhibitors, such as PD-1/PD-L1 and CTLA-4, has played an importantcheckpoint inhibitors.Clinical practice has revealed that antibiotics can weaken the therapeutic response to immune checkpointStudies have shown that the gut microbiota is essential for the interaction between immune checkpointThis review focuses on the interactions between immune checkpoint inhibitors and antibiotics, with an

Keywords： tumor immunotherapy     immune checkpoint inhibitor     antibiotics     gut microbiota     drug–drug interaction    

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Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 773-783 doi: 10.1007/s11684-021-0902-1

Abstract: The total number of cancer patients who are eligible for and will benefit from immune checkpoint inhibitorspatients with eligibility and response to ICIs based on the 2015 Chinese cancer statistics and the immunecheckpoint inhibitor clinical practice guideline of the Chinese Society of Clinical Oncology.

Keywords： benefit     China     eligibility     immune checkpoint inhibitor     public health    

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Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection

Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 260-267 doi: 10.15302/J-FASE-2016116

Abstract: The innate immune response is the first line of defense against viral invasion and pro-inflammatory chemokinesand cytokines have a critical function in the innate immune responses against virus infections.leukocytes into the CNS, enhancement of blood brain barrier permeability and activation of various immuneIn addition, recombinant RABV expressing cytokines and chemokines can induce elevated innate and adaptiveimmune responses which result in clearing an established wild-type RABV infection in the CNS.

Keywords： antiviral     blood brain barrier     chemokines and cytokines     innate immunity     rabies virus    

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Liver-directed treatment is associated with improved survival and increased response to immune checkpoint

Frontiers of Medicine   Pages 878-888 doi: 10.1007/s11684-023-0993-y

Abstract: A total of 182 patients with metastatic UM treated with immune checkpoint blockade (ICB) were included

Keywords： uveal melanoma     liver-directed therapy     immune checkpoint blockade     SIRT     anti-PD-1     anti-CTLA-4    

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Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy

Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 32-44 doi: 10.1007/s11684-018-0678-0

Abstract: In particular, immune checkpoint inhibitors are proved to be unprecedentedly in increasing the overallTherefore, doctors urgently need reliable predictive biomarkers for checkpoint inhibitor therapies toHere, we review the biomarkers that can serve as potential predictors of the outcomes of immune checkpoint

Keywords： immune checkpoint     companion diagnosis     PD-L1     tumor mutation burden     immune score    

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Activation of phagocytosis by immune checkpoint blockade

Chia-Wei Li, Yun-Ju Lai, Jennifer L. Hsu, Mien-Chie Hung

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 473-480 doi: 10.1007/s11684-018-0657-5

Abstract:

Inhibition of macrophage-mediated phagocytosis has emerged as an essential mechanism for tumor immuneOne mechanism inhibiting the innate response is the presence of the macrophage inhibitory molecule, signalAs more and more immune receptors are found to be expressed on TAMs, the corresponding therapies may

Keywords： CD47     PD-1     PD-L1     immunotherapy     TAM     phagocytosis     macrophage    

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Immunometabolism: a new dimension in immunotherapy resistance

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 585-616 doi: 10.1007/s11684-023-1012-z

Abstract: Immune checkpoint inhibitors (ICIs) have demonstrated unparalleled clinical responses and revolutionizedof metabolic intervention with ICIs to reap synergic benefits and facilitate an adjusted anti-tumor immune

Keywords： immune cell     immunometabolism     metabolic reprogramming     immunotherapy     resistance     tumor microenvironment     immune checkpoint inhibitor    

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Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Frontiers of Medicine doi: 10.1007/s11684-023-1016-8

Abstract: In the DETECT trial, decitabine induced strong immune responses featuring the striking upregulation ofthe innate immune player IRF7 in the p53-mutated TNBC cell line (upregulation by 16-fold) and

Keywords： p53 mutation     triple-negative breast cancer     decitabine     DNMT1     IRF7     innate immune response    

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Diverse Roles of Immune Cells in Transplant Rejection and Immune Tolerance Review

Xiaojie Gan, Jian Gu, Zheng Ju, Ling Lu

Engineering 2022, Volume 10, Issue 3,   Pages 44-56 doi: 10.1016/j.eng.2021.03.029

Abstract:

Organ transplant rejection (OTR) is a complex immune reaction involvingHowever, immunosuppressive agents negatively impact the immune system of the patients, causing them toTherefore, a thorough understanding of the mechanisms involved in immune tolerance and immune rejectionThis article reviews the role of immune cells in OTR and organ transplant tolerance (OTT), including

Keywords： Immune cells     Innate immune cells     Adaptive immune cells     Organ transplant     Immune tolerance    

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Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future directions

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 18-42 doi: 10.1007/s11684-022-0976-4

Abstract: Furthermore, the therapeutic role of immune-checkpoint inhibitors (ICIs) in oncogene-driven NSCLC remainsdriver mutations and the combined therapeutic approaches that might reverse the immunosuppressive tumor immune

Keywords： non-small cell lung cancer     driver mutations     treatment strategy     resistant mechanism     immune-checkpoint    

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Title Author Date Type Operation

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Journal Article

Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Journal Article

Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases

Zhen Xiang, Yingyan Yu

Journal Article

Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Journal Article

Innate immune responses in RNA viral infection

Qian Xu, Yuting Tang, Gang Huang

Journal Article

Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy

Journal Article

Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors

Journal Article

Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection

Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU

Journal Article

Liver-directed treatment is associated with improved survival and increased response to immune checkpoint

Journal Article

Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy

Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian

Journal Article

Activation of phagocytosis by immune checkpoint blockade

Chia-Wei Li, Yun-Ju Lai, Jennifer L. Hsu, Mien-Chie Hung

Journal Article

Immunometabolism: a new dimension in immunotherapy resistance

Journal Article

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Journal Article

Diverse Roles of Immune Cells in Transplant Rejection and Immune Tolerance

Xiaojie Gan, Jian Gu, Zheng Ju, Ling Lu

Journal Article

Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future directions

Journal Article